The OTOSTEM consortium addresses differentiation, proliferation and biological activity/potency auditory sensory or neuronal cells in the cochlea by a unique consortium of leading academic laboratories in Europe and the USA as well as two European SMEs fully dedicated to the development of regenerative hearing loss therapies.

The consortium presents a systematic plan to overcome the prevailing roadblocks that impede the development of translational approaches toward novel human cell-based and drug-based treatments for hearing loss.


All academic members of the consortium have a proven track record in the area of inner ear regeneration and stem cell technology. The laboratories have complementary expertise with clear evidence of well-conceived, ongoing collaborations.

For the field of hearing loss, such an international collaboration is unprecedented and will clearly expedite the development of stem applications for the treatment for patients suffering from hearing loss and deafness.
Partner 1 - EKUT (Coordinator)
Eberhard Karls Universität Tübingen, University of Tübingen Medical Centre, Department of Otolaryngology - Head & Neck Surgery and Institute of Anatomy
Prof. Dr. med. Hubert Löwenheim (Coordinator)
Priv.-Doz. Dr. phil. nat. Marcus Müller
Tübingen, Germany
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Partner 2 - UNIBE
University of Bern
PD Dr. med. P. Senn
Prof. Dr. S. Leib
Bern, Switzerland
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Partner 3 - UoS
University of Sheffield
Dr. Marcelo N. Rivolta
Sheffield, United Kingdom
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Partner 4 - AMU
Aix-Marseille University
Prof. Azel Zine
Marseille, France
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Partner 5 - UU
Uppsala University
Prof. Rask Andersen
Uppsala, Sweden
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Partner 6 - Stanford
Stanford University
Prof. Stefan Heller
Stanford, United States
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Partner 7 - MEEI
Massachusetts Eye and Ear Infirmary
Dr. Albert Edge
Boston, United States
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Partner 8 - Audion
Audion Therapeutics BV
Dr. Helmuth van Es
Rolf Jan Rutten
Amsterdam, The Netherlands
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Partner 9 - Acousia
Acousia Therapeutics GmbH
Dr. Michael Bös
Tübingen, Germany
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Partner 10 - SCIPROM
SCIPROM Sàrl
Dr. Kirsten Leufgen
Dr. Véronique Gobry
Filippo Gander
St-Sulpice, Switzerland
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The OTOSTEM project has received funding from the European Community's Seventh Framework Programme under grant agreement No. 603029.