Innovative Medicines Initiative (IMI) 2 Call 13: Indicative Topics Published

IMI 2 has just published a list of indicative topics for the call 13 which is foreseen to be launched before the end of the year.

The following topics are under consideration for inclusion in future IMI calls for proposals:

- Assessment of the uniqueness of diabetic cardiomyopathy relative to other forms of heart failure using unbiased pheno-mapping approaches
- Genome-environment interactions in inflammatory skin disease
- The value of diagnostics to combat antimicrobial resistance by optimising antibiotic use
- Mitochondrial dysfunction in neurodegeneration
- Support and coordination action for the projects of the neurodegeneration area of the Innovative Medicines Initiative
- A sustainable European induced pluripotent stem cell platform
- Linking digital assessment of mobility to clinical endpoints to drive regulatory acceptance and clinical practice
- Human tumour microenvironment immunoprofiling
- CONCEPTION - continuum of evidence from pregnancy exposures, reproductive toxicology and breastfeeding to improve outcomes now
- Improving the preclinical prediction of adverse effects of pharmaceuticals on the nervous system
- Translational safety biomarker pipeline (TRANSBIOLINE): enabling development and implementation of novel safety biomarkers in clinical trials and diagnosis of disease
- Federated and privacy-preserving machine learning in support of drug discovery
- Pilot programme on a clinical compound bank for repurposing. This programme includes the following topics: Cardiovascular diseases and diabetes, Respiratory diseases, Neurodegenerative diseases and Rare/orphan diseases

Source: IMI2

OTOSTEM releases its second publishable summary

The second publishable summary of OTOSTEM is now available online.

This document summarises the progress in the second 18 months of the project.

New publications by OTOSTEM

Three new research articles by OTOSTEM partners from Uppsala University, Massachusetts Eye and Ear Infirmary( MEEI) and Stanford University have been published recently:
  • The effect of pulsed electric fields on the electrotactic migration of human neural progenitor cells through the involvement of intracellular calcium signaling. Hisamitsu Hayashi, Fredrik Edin, Hao Li, Wei Liu, and Helge Rask-Andersen. Brain Research 1652 (2016): 195-203. doi: 10.1016/j.brainres.2016.09.043 
  • Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs. Will J. McLean, Dalton T. McLean, Ruth Anne Eatock, and Albert S. B. Edge. Development (2016): dev.139840. doi: 10.1242/dev.139840
  • Single-cell analysis delineates a trajectory toward the human early otic lineage. Megan Ealy, Daniel C. Ellwanger, Nina Kosaric, Andres P. Stapper, and Stefan Heller. Proceedings of the National Academy of Sciences 113, no. 30 (2016): 8508-8513. doi: 10.1073/pnas.1605537113

OTOSTEM Publications

The OTOSTEM website now lists all publications in peer-reviewed scientific journals and several other public documents including a publishable summary which summarises the progress in the first 18 months of the project.

OTOSTEM flyers available

The OTOSTEM flyer is now available! You can download it here

OTOSTEM at the IEB meeting in Sheffield

OTOSTEM was presented at the Inner Ear Biology Workshop (IEB 2014) in Sheffield. For the conference programme and abstracts please refer to the workshop website . The consortium further took this opportunity for an internal meeting right after the workshop. 

OTOSTEM full website online

We are happy to announce that the OTOSTEM full website is now online. It will be our pleasure to update it constantly with news, events and project achievements.


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The OTOSTEM project has received funding from the European Community's Seventh Framework Programme under grant agreement No. 603029.